LEY 25467 PDF

Article number: Author biographies PDF version. There is a long tradition of paleontological research in Argentina. These were mainly remains of Megatherium Figure 1. Between and , during his famous voyage on the H. Beagle, Charles Darwin visited several Argentinian localities, where he collected numerous fossils and made important geological observations Aguirre-Urreta et al.

Author:Akigore Netaur
Language:English (Spanish)
Published (Last):19 July 2004
PDF File Size:19.52 Mb
ePub File Size:8.18 Mb
Price:Free* [*Free Regsitration Required]

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Free to read. In transiently transfected chicken erythroid cells, beta-like globin gene switching is mediated through differential activation of the cis-linked embryonic epsilon- and adult beta-globin genes by a shared enhancer. Two underlying mechanisms have been proposed: i tissue- and stage-specific factors activate the beta-globin promoter in adult erythroid cells autonomous regulation ; and ii the epsilon-globin promoter, although transcriptionally competent in both embryonic and adult cells, is suppressed at the adult stage through competition with the beta-globin promoter for interaction with the enhancer competitive regulation.

Surprisingly, the chicken epsilon-globin gene also appeared to be autonomously regulated, as has been observed for human embryonic and fetal beta-like globin genes in transgenic mice.

Read article at publisher's site DOI : Lorberbaum DS , Barolo S. Curr Biol , 25 7 :R, 01 Mar J Mol Endocrinol , 47 2 , 30 Aug Cited by 2 articles PMID: Dev Dyn , 7 , 01 Jul Cited by 7 articles PMID: J Biol Chem , 24 , 11 Apr Cited by 3 articles PMID: Mol Cell Biol , 23 24 , 01 Dec To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

J Biol Chem , 41 , 01 Oct Genes Dev , 6 5 , 01 May Cited by 59 articles PMID: Nickol JM , Felsenfeld G. J Cell Sci Suppl , , 01 Jan Cited by 12 articles PMID: Cited by 1 article PMID: Coronavirus: Find the latest articles and preprints. Europe PMC requires Javascript to function effectively. Recent Activity. Recent history Saved searches.

Search articles by 'K P Foley'. Foley KP 1 ,. S Pruzina Search articles by 'S Pruzina'. Pruzina S ,. Winick JD ,. Engel JD ,. F Grosveld Search articles by 'F Grosveld'. Grosveld F ,. P Fraser Search articles by 'P Fraser'. Fraser P. Affiliations 1 author 1. Share this article Share with email Share with twitter Share with linkedin Share with facebook.

Free full text. Author information Copyright and License information Disclaimer. Copyright notice. This article has been cited by other articles in PMC. Abstract In transiently transfected chicken erythroid cells, beta-like globin gene switching is mediated through differential activation of the cis-linked embryonic epsilon- and adult beta-globin genes by a shared enhancer.

Images in this article Image on p. Image on p. Chromosomal arrangement of the chicken beta-type globin genes. The erythroid cells and haemoglobins of the chick embryo. A 3' enhancer is required for temporal and tissue-specific transcriptional activation of the chicken adult beta-globin gene.

Developmental regulation of beta-globin gene switching. Regulated gene expression in transfected primary chicken erythrocytes. Bidirectional control of the chicken beta- and epsilon-globin genes by a shared enhancer. Genes Dev. Individual stage selector element mutations lead to reciprocal changes in beta- vs.

Developmental regulation of human beta-globin gene transcription: a switch of loyalties? Trends Genet. Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Autonomous developmental control of human embryonic globin gene switching in transgenic mice. Developmentally regulated and erythroid-specific expression of the human embryonic beta-globin gene in transgenic mice.

Nucleic Acids Res. Human gamma-globin genes silenced independently of other genes in the beta-globin locus. Human gamma- to beta-globin gene switching in transgenic mice. Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice. Importance of globin gene order for correct developmental expression. Role of gene order in developmental control of human gamma- and beta-globin gene expression.

Mol Cell Biol. Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes. Analysis of the adult chicken beta-globin gene. Nucleotide sequence of the locus, microheterogeneity at the 5'-end of beta-globin mRNA, and aberrant nuclear RNA species. J Biol Chem. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. The complete sequence of a chromosomal mouse alpha--globin gene reveals elements conserved throughout vertebrate evolution.

The nucleotide sequence of the embryonic chicken beta-type globin genes. Site-independent expression of the chicken beta A-globin gene in transgenic mice. J Mol Biol. Quantitation of RNA using the polymerase chain reaction. Regulated expression of globin chains and the erythroid transcription factor GATA-1 during erythropoiesis in the developing mouse. Developmental regulation of a complete kb human beta-globin locus in transgenic mice.

Regulated expression of human A gamma-, beta-, and hybrid gamma beta-globin genes in transgenic mice: manipulation of the developmental expression patterns. Expression of adult and tadpole specific globin genes from Xenopus laevis in transgenic mice. An embryonic pattern of expression of a human fetal globin gene in transgenic mice.

An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes. Functional properties of the beta-globin locus control region in K erythroleukemia cells.

Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression. EMBO J. Globins: a case study in molecular phylogeny. Associated Data Supplementary Materials.

Open in a separate window. Smart citations by scite. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles. Explore citation contexts and check if this article has been supported or contradicted.

Enhancers: holding out for the right promoter. Identification, characterization, and expression pattern of the chicken EKLF gene. Targeted deletion of the chicken beta-globin regulatory elements reveals a cooperative gene silencing activity. Human beta-globin locus control region HS5 contains CTCF- and developmental stage-dependent enhancer-blocking activity in erythroid cells. Developmental control of epsilon- and gamma-globin genes.

This website requires cookies, and the limited processing of your personal data in order to function.


PDF Institucionalidad

These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online.


Jump to a detailed profile, search site with google or try advanced search. Funkley, MN residents, houses, and apartments details. Latest news from Funkley, MN collected exclusively by city-data. Nearest city with pop. Nearest cities: Blackduck, MN 2.


Kingsley Edugroup Ltd. If you are an existing subscriber, please login. If not, read up on what you are missing out in our Help Centre and join us as a subscriber. While reasonable efforts have been taken to ensure that the calculations performed by the features of this site are reliable, the features are provided on the basis that

Related Articles