Plants of the genus Byrsonima , which is composed of approximately of species, are widely distributed throughout tropical America. Byrsonima intermedia A. Pharmacological pre-clinical studies from this species have proved the anti-inflammatory, antinociceptive, antioxidant, antimicrobial, antidiarrheal and anti-ulcerogenic properties of this plant. Chemical studies of this species have shown the correlation of these activities with the presence of terpenoids, flavonoids and tannins. These evaluations showed the medicinal potential of this plant; however, the presence of the in vitro mutagenicity effect requires the careful assessment of the medicine used. Skip to main content.
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Byrsonima intermedia is a species of bush popularly used to treat gastrointestinal disorders, such as gastric ulcers, gastritis, and diarrhea. Previous studies have revealed that the methanolic crude extract of B. In this new study, we specifically investigated two purified partitions, ethyl acetate EtOAc and water AcoAq , obtained from the crude extract to characterize the antiulcer effects of these two partitions and the mechanisms of action of this medicinal plant.
The antibacterial activity against Helicobacter pylori was evaluated using microdilution methods. The phytochemical analysis of AcoAq revealed a predominance of oligomeric proanthocyanidins and galloyl quinic esters, whereas EtOAc was found to contain concentrated flavonoids. Both partitions led to a significant reduction in gastric lesions, but AcoAq was more effective than EtOAc with regard to anti-Helicobacter pylori activity in addition to protecting the gastric mucosa against ethanol, non-steroidal anti-inflammatory drugs NSAIDs and duodenal mucosal damage induced by cysteamine.
Additionally, both partitions were associated with a significant increase in gastric and duodenal healing and increased gastric mucosal GSH content after damage induced by acetic acid. These results demonstrate that the oligomeric proanthocyanidins and galloyl quinic esters present in AcoAq were more effective in the prevention of gastric and duodenal ulcers due to the antioxidant effects of these compounds, whereas the flavonoids present in EtOAc were more effective due to their anti-inflammatory activity on the gastric and duodenal tissue.
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Byrsonima intermedia A.Juss.
Ethnopharmacological relevance: An ethnopharmacological survey indicated that the leaves of Byrsonima intermedia A. Malpighiaceae , a medicinal species commonly found in the Brazilian Cerrado, can be used against gastroduodenal disorders, such as gastric ulcers and diarrhea. Aim of the study: The objective of this study was to evaluate the effects of a methanolic extract of Byrsonima intermedia MBI leaves on gastric and duodenal ulcers and to assess the antimicrobial and antidiarrheal effects of this extract. The gastroprotective effect of MBI was assessed by analysing the volume of gastric juice, pH, total acidity, mucus, NO, sulfhydryl compound, vanilloid receptor, glutathione GSH levels, and myeloperoxidase MPO activity in the gastric and duodenal mucosa. The gastric and duodenal healing effects of MBI were also evaluated during 7 or 14 days of treatment. The antidiarrheal action measured by intestinal motility and diarrhea induced by castor oil and anti-bacterial action of MBI against Staphylococcus aureus, Escherichia coli and Helicobacter pylori were also evaluated by microdilution methods.