AMILOIDOSIS MACULAR PDF

DermNet provides Google Translate, a free machine translation service. Note that this may not provide an exact translation in all languages. Amyloidosis is the term used for a group of diseases where one or more body organs accumulate various insoluble proteins amyloid in amounts to cause dysfunction of the organ system. Organs often affected include the heart, kidney, gastrointestinal tract, nervous system and skin. Amyloidosis of the skin is called cutaneous amyloidosis. In this condition, amyloid or amyloid-like proteins are deposited in the dermis.

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Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed. Macular amyloidosis MA is a rare chronic form of cutaneous amyloidosis see this term , a skin disease characterized by the accumulation of amyloid deposits in the dermis, clinically characterized by pruritic hyperkeratotic gray-brown macules that give a rippled or reticulated pattern of pigmentation usually in the upper back and extensor sites of arms, forearms and legs, and histologically by the deposition of amyloid in the upper dermis and close to the basal cell layer of the epidermis.

MA is commonly associated with other skin diseases, such as atopic dermatitis. Other search option s Alphabetical list. Suggest an update. Summary and related texts. Related genes. Clinical signs.

Check this box if you wish to receive a copy of your message. Disease definition Macular amyloidosis MA is a rare chronic form of cutaneous amyloidosis see this term , a skin disease characterized by the accumulation of amyloid deposits in the dermis, clinically characterized by pruritic hyperkeratotic gray-brown macules that give a rippled or reticulated pattern of pigmentation usually in the upper back and extensor sites of arms, forearms and legs, and histologically by the deposition of amyloid in the upper dermis and close to the basal cell layer of the epidermis.

Additional information Further information on this disease Classification s 1 Gene s 0 Other website s 0. Health care resources for this disease Expert centres 28 Diagnostic tests 1 Patient organisations 12 Orphan designation s and orphan drug s 0. Specialised Social Services Eurordis directory.

The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.

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Macular Amyloidosis (Friction Amhyloidosis)

Macular amyloidosis typically presents as gray-brown pruritic macules, which gradually coelesce into patches with a rippled pattern involving the upper back Figure 1 and less often the arms, chest and thighs. Macular amyloidosis is one of the more common types of primary localized cutaneous amyloidoses. The three main forms of primary localized cutaneous amyloidosis are lichen amyloidosis, macular amyloidosis, and nodular amyloidosis. Patients can sometimes have physical findings of both lichen amyloidosis and macular amyloidosis, known as biphasic amyloidosis. Figure 1. Macular amyloid on the back.

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Amyloidosis

DermNet provides Google Translate, a free machine translation service. Note that this may not provide an exact translation in all languages. The two primary cutaneous amyloidoses lichen and macular amyloidosis show similar histological features and so are described together. The scanning power view of primary cutaneous amyloidosis can be relatively unremarkable figure 1. The key component of the histology is the deposition of pink amorphous material within the papillary dermis. This forms a number of scattered and confluent globular deposits figures 2, 3, 4.

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Macular Amyloidosis

Amyloidosis am-uh-loi-DO-sis is a rare disease that occurs when an abnormal protein, called amyloid, builds up in your organs and interferes with their normal function. Amyloid isn't normally found in the body, but it can be formed from several different types of protein. Organs that may be affected include the heart, kidneys, liver, spleen, nervous system and digestive tract. Some varieties of amyloidosis occur in association with other diseases. These types may improve with treatment of the underlying disease. Some varieties of amyloidosis may lead to life-threatening organ failure. Treatments may include chemotherapy similar to that used to combat cancer.

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