GLUTAMINASE THESIS PDF

Masters thesis, Indian Institute of Technology Hyderabad. L - Asparaginase is an amidohydrolase that catalyzes the hydrolysis of amino acid L - aspar a gine in to aspartic acid and ammonia. It is also used in food industry to prevent the formation of a crylamide , a carcinogenic substance in carbohydrate rich fried and baked foods. Naturally L - Asparaginase is present i n plants, animals and microbes but microorganisms such as bacteria, yeast and fungi are generally used for the production of L - Asparaginase as it is difficult to obtain the same from plants and animals. It is found that the L - Asparaginase from bacteria causes side effects in humans including anaphylaxis and serious allergic reactions which can be fatal in some cases. To overcome this, eukaryotic organisms such as fungi can be used for the production of L - Asparaginase.

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Glutamate serves as a crucial excitatory neurotransmitter that is essential for the proper functioning of the brain. However, excess levels of glutamate are neurotoxic and contribute to the pathogenesis of various neurodegenerative diseases, inducing HIV-1 associated neurocognitive disorders HAND. Glutaminase 1 GLS1 is an important mitochondrial enzyme responsible for producing glutamate from glutamine. However, why and how GLS1 is released remains unknown.

Therefore, we hypothesize that the release of EV is dependent on GLS1-mediated glutamine and sphingolipid metabolism. Biogenesis of EVs requires the sphingolipid ceramide.

In summary, our data revealed two interesting insights into the biology of EVs. Studies on both of these aspects in EVs could lead to potential novel therapeutic targets for HAND and other neurodegenerative diseases. Advanced Search. Privacy Copyright. Skip to main content University of Nebraska Medical Center. Programs Pharmacology and Experimental Neuroscience. Abstract Glutamate serves as a crucial excitatory neurotransmitter that is essential for the proper functioning of the brain.

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Essay: L-glutaminase

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Glutamate serves as a crucial excitatory neurotransmitter that is essential for the proper functioning of the brain. However, excess levels of glutamate are neurotoxic and contribute to the pathogenesis of various neurodegenerative diseases, inducing HIV-1 associated neurocognitive disorders HAND. Glutaminase 1 GLS1 is an important mitochondrial enzyme responsible for producing glutamate from glutamine. However, why and how GLS1 is released remains unknown.

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GLUTAMINASE THESIS PDF

Levels of L-glutaminase activities in soils at pH 8 and pH Effect of substrate. This free Science essay on L-glutaminase is perfect for Science students to use as an example. In this thesis we report our structural and functional studies on KGA and its metabolism and a key metabolic enzyme, glutaminase. In the chapter II. Over a insufficient decades, considerable research has been undertaken with the microbial production of extracellular L-glutaminase. Further Goldstein, and Schooler, et al. The enzyme precipitate obtained from each saturation was dissolved in a minimal volume of 0.

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This page of the essay has words. Download the full version above. Microbial enzymes are identified to play a central role as metabolic catalysts, leading to their usage in various productions and applications , the end usage market for industrial enzymes is tremendously wide-spread with frequent industrial profitable applications Adrio, et al. Over industrial products are being complete using enzymes Kumar, and Singh, et al. The request for industrial enzymes is on a incessant rise driven by a growing necessity for maintainable solutions.

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