Coronavirus News Center. The large antihyperlipidemic class of drugs can be subdivided into bile acid sequestrants, HMG-CoA reductase inhibitors, fibric acid derivatives, ezetimibe, and niacin. With the possible exception of familial hypercholesterolemia, there appears to be no maternal benefit for the treatment of hyperlipidemia during gestation. Nearly all reported pregnancy exposures have occurred accidentally. If treatment is required, only bile acid sequestrants are considered compatible in pregnancy and lactation.
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No Downloads. Views Total views. Actions Shares. Embeds 0 No embeds. No notes for slide. Antihyperlipidemic drugs 1. What is Hyperlipidemia? Causes of hyperlipidemia 4. Lipids are the heterogenous mixtures of fatty acids and alcohol that are present in the body.
Is C27 steroid that serves as an important component of all cell membranes and important precursor molecule for the biosynthesis of bile acids, steroid hormones, and several fat-soluble vitamins Cholesterol 6. Triglycerides either meet immediate energy needs in muscles or stored as fat for future energy requirements. A lipoprotein contains both proteins and lipids, bound to another proteins which is called apolipoproteins, which allow fats to move through the water inside and outside cells.
It does not directly account for HDL, and it does not distinguish among the different genes that may be partially responsible for some of these conditions.
Several different classes of drugs are used toSeveral different classes of drugs are used to treat hyperlipidemia. These classes differ nottreat hyperlipidemia.
These classes differ not only in theironly in their mechanism of actionmechanism of action but also inbut also in the type of lipid reduction and the magnitudethe type of lipid reduction and the magnitude ofof the reduction. Bicyclic rings could be replaced with other lipophlic rings, size and shape of it are important for activity c.
Hyperlipidemia Fenofibrate Headache, dizziness, asthaenia, fatigue, arrhythmia More potent hypercholesterolemic and triglycerides lowering agent Cholestyramine Questran Colesevalam Adverse effects Therapeutic Uses It acts by decreasing cholesterol absorption in the intestine Mechanism of action Cholesterol Absorption Inhibitor Therapeutic uses A sustained release dosage form is available Serious liver damage is the most important risk. Niacin Nicotinic Acid LDL oxidation inhibitor probucol Use: It is used as antihyperlipoproteinemic agent.
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If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus. Atherosclerosis is the abnormal accumulation of lipids and products resulting from an inflammatory response in the walls of arteries, and is the leading cause of death in the Western world. Heart attacks, angina pectoris, peripheral arterial disease, and strokes are common sequelae of atherosclerosis. In some cases, lowering serum lipid concentrations has been shown to prevent the sequelae of atherosclerosis and decrease mortality in patients with a history of cardiovascular disease and hyperlipidemia. The five drug classes discussed in this chapter Figure 26—1 are used to decrease serum concentrations of lipids in the blood hyperlipidemia and to prevent or reverse associated atherosclerosis, or, in the case of hypertriglyceridemia, prevent pancreatitis. Although the drugs are generally safe and effective, adverse effects include drug—drug interactions and rare toxic reactions in skeletal muscle and the liver. The five classes of lipid-lowering drugs.
Antihyperlipidemic agents promote reduction of lipid levels in the blood. Some antihyperlipidemic agents aim to lower the levels of low-density lipoprotein LDL cholesterol, some reduce triglyceride levels, and some help raise the high-density lipoprotein HDL cholesterol. By reducing the LDL cholesterol, they can prevent both the primary and secondary symptoms of coronary heart disease. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.