These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric. Find more information on the Altmetric Attention Score and how the score is calculated.
|Published (Last):||23 March 2009|
|PDF File Size:||19.95 Mb|
|ePub File Size:||2.80 Mb|
|Price:||Free* [*Free Regsitration Required]|
Choose a collection: Unable to load your collection due to an error Please try again. Add Cancel. Add to My Bibliography My Bibliography.
Unable to load your delegates due to an error Please try again. Your saved search Name of saved search:. Search terms:. Test search terms. Would you like email updates of new search results? Email: change. Frequency: Monthly Weekly Daily. Which day? Send at most: 1 item 5 items 10 items 20 items 50 items items items. Send even when there aren't any new results. Optional text in email:. Save Cancel. Create a file for external citation management software Create file Cancel. Full-text links Cite Favorites.
Similar articles Metal complexes in medicinal chemistry: new vistas and challenges in drug design. Thompson KH, Orvig C. Thompson KH, et al. Dalton Trans. Epub Nov PMID: The identification of potent, selective, and bioavailable cathepsin S inhibitors. Gauthier JY, et al. Bioorg Med Chem Lett. Epub Jun Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects.
Costanzi S, et al. J Biol Chem. Epub Apr 2. No abstract available. Random molecular fragment methods in computational medicinal chemistry. Lounkine E, et al. Curr Med Chem. PMID: Review. Synthesis of the new pseudo-symmetrical tamoxifen derivatives and their anti-tumor activity.
Shiina I, et al. Epub Feb Show more similar articles See all similar articles. Hejazi L, et al. Iran J Pharm Res. Ortiz C, et al. Lizard G, et al. Wang T, et al. Show more "Cited by" articles See all "Cited by" articles. Publication types Review Actions. MeSH terms Animals Actions. Drug Evaluation, Preclinical Actions. Humans Actions. Molecular Conformation Actions. Stereoisomerism Actions. Structure-Activity Relationship Actions. Full-text links [x] Bentham Science Publishers Ltd.
Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design
In medicinal chemistry , bioisosteres are chemical substituents or groups with similar physical or chemical properties which produce broadly similar biological properties to another chemical compound. In drug design ,  the purpose of exchanging one bioisostere for another is to enhance the desired biological or physical properties of a compound without making significant changes in chemical structure. The main use of this term and its techniques are related to pharmaceutical sciences. Bioisosterism is used to reduce toxicity, change bioavailability , or modify the activity of the lead compound, and may alter the metabolism of the lead. Classical bioisosterism was originally formulated by James Moir and refined by Irving Langmuir  as a response to the observation that different atoms with the same valence electron structure had similar biological properties. For example, the replacement of a hydrogen atom with a fluorine atom at a site of metabolic oxidation in a drug candidate may prevent such metabolism from taking place.