Andrographis paniculata plant extract is known to possess a variety of pharmacological activities. Andrographolide, the major constituent of the extract is implicated towards its pharmacological activity. We studied the cellular processes and targets modulated by andrographolide treatment in human cancer and immune cells. Andrographolide treatment inhibited the in vitro proliferation of different tumor cell lines, representing various types of cancers. Immunostimulatory activity of andrographolide is evidenced by increased proliferation of lymphocytes and production of interleukin
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Andrographis paniculata plant extract is known to possess a variety of pharmacological activities. Andrographolide, the major constituent of the extract is implicated towards its pharmacological activity. We studied the cellular processes and targets modulated by andrographolide treatment in human cancer and immune cells.
Andrographolide treatment inhibited the in vitro proliferation of different tumor cell lines, representing various types of cancers.
Immunostimulatory activity of andrographolide is evidenced by increased proliferation of lymphocytes and production of interleukin Andrographolide also enhanced the tumor necrosis factor-alpha production and CD marker expression, resulting in increased cytotoxic activity of lymphocytes against cancer cells, which may contribute for its indirect anticancer activity.
The in vivo anticancer activity of the compound is further substantiated against B16F0 melanoma syngenic and HT xenograft models.
These results suggest that andrographolide is an interesting pharmacophore with anticancer and immunomodulatory activities and hence has the potential for being developed as a cancer therapeutic agent.
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Abstract Andrographis paniculata plant extract is known to possess a variety of pharmacological activities. Similar articles Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer. Islam MT, et al. Cancer Lett. Epub Feb PMID: Anticancer and immunostimulatory compounds from Andrographis paniculata.
Kumar RA, et al. J Ethnopharmacol. Andrographis paniculata extracts and major constituent diterpenoids inhibit growth of intrahepatic cholangiocarcinoma cells by inducing cell cycle arrest and apoptosis. Suriyo T, et al. Planta Med.
Epub Apr Andrographolide and analogues in cancer prevention. Mishra SK, et al. Front Biosci Elite Ed. PMID: Review. Qi CL, et al. Zhongguo Zhong Yao Za Zhi.
Show more similar articles See all similar articles. Pooladanda V, et al. Life Sci. Online ahead of print. Loh SH, et al. Cancers Basel. Xie S, et al. Int J Biol Sci. Rajaratinam H, et al. Malays J Med Sci. Epub Nov 4. Pearngam P, et al.
Front Pharmacol. Show more "Cited by" articles See all "Cited by" articles. Publication types Research Support, Non-U. Gov't Actions. Animals Actions. Blotting, Western Actions. Flow Cytometry Actions. Humans Actions. Mice Actions. Transplantation, Heterologous Actions. Substances Antineoplastic Agents, Phytogenic Actions.
Diterpenes Actions. Interleukin-2 Actions. Plant Extracts Actions. Full-text links [x] Wiley. Copy Download.
Anticancer and immunostimulatory compounds from Andrographis paniculata.
Salinity causes the adverse effects in all physiological processes of plants. The present study aimed to investigate the potential of salt stress to enhance the accumulation of the anticancer phytochemicals in Andrographis paniculata accessions. For this purpose, day-old plants were grown in different salinity levels 0. After inducing a period of day salinity stress and before flowering, all plants were harvested and the data on morphological traits, proline content and the three anticancer phytochemicals, including andrographolide AG , neoandrographolide NAG , and deoxy,didehydroandrographolide DDAG , were measured.
Andrographolide, a Potential Cancer Therapeutic Agent Isolated From Andrographis Paniculata
Andrographis paniculata and Silybum marianum are well known medicinal plants. However, to prove their efficacy for clinical utilization more scientific data are needed. Therefore, in the present study, an attempt was made to investigate the anticancer potential of hydroalcoholic extracts of A. The sulphorhodamine B SRB assay was used to assess growth inhibition of human tumor.