Microcytic anaemia is any of several types of anaemia characterized by small red blood cells called microcytes. The normal mean corpuscular volume abbreviated to MCV on full blood count results, and also known as mean cell volume is approximately 80— fL. The MCV is the average red blood cell size. In microcytic anaemia, the red blood cells erythrocytes contain less hemoglobin and are usually also hypochromic , meaning that the red blood cells appear paler than usual.
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Chiattone 2. Resposta medular inadequada. A ferritinemia encontra-se normal ou aumentada. Tais medidas devem ser consideradas caso a caso 11, 12, Abstract The anemia of chronic disease ACD is usually defined as the anemia occurring in chronic infectious, inflammatory disorders, or neoplastic diseases, and is one of the most common syndromes in the clinical practice.
The three principal pathologic mechanisms involved in ACD are: reduced erythrocyte survival, bone marrow failure to increase red blood cell production to compensate for the increase in its demand, and abnormal mobilization of reticuloendothelial iron stores. The central role of monocytes and macrophages, and the increased production of the cytokines that mediate the immune or inflammatory response, such as tumor necrosis factor, interleukin-1 and the interferons, are implicated in all three processes involved in the development of ACD.
The aim of this article is to review the recent advances in the understanding of the pathophysiologic, diagnostic and therapeutic aspects of this syndrome. Keywords: Anemia of chronic disease, erythropoiesis, cytokines, tumor necrosis factor, interleukin, interferon. Hansen NE.
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CEP: SP E-mail: rdcan uol. Services on Demand Journal. Anemia of chronic disease Abstract The anemia of chronic disease ACD is usually defined as the anemia occurring in chronic infectious, inflammatory disorders, or neoplastic diseases, and is one of the most common syndromes in the clinical practice. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.
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Chiattone 2. Resposta medular inadequada. A ferritinemia encontra-se normal ou aumentada. Tais medidas devem ser consideradas caso a caso 11, 12,