FISIOPATOLOGIA DE LA GASTROPARESIA PDF

Nenhuma das mulheres estava na menopausa, sendo que todos os estudos foram realizados durante a primeira fase do ciclo menstrual. Com estes dados foram obtidas curvas de tempo versus contagem radioativa. Valores de P menores que 0,05 foram considerados como estatisticamente significativos. Scintigraphic study of gastric emptying and intragastric distribution of a solid meal: gender differences. Arq Gastroenterol ;37 2

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Universidad Rey Juan Carlos. La diabetes mellitus DM es un conjunto de enfermedades de gran prevalencia en la actualidad. Para ello se describen las diversas alteraciones funcionales y estructurales encontradas en el sistema digestivo tanto en el hombre como en diversos modelos animales de diabetes. Palabras clave: Diabetes mellitus. Dismotilidad gastrointestinal.

Diabetes mellitus DM is a group of diseases highly prevalent nowadays. Its different types produce very similar symptoms with acute and chronic complications. Amongst these, gastrointestinal GI dysmotility, associated with the development of neuropathy in the enteric nervous system ENS is recognized. The objective is to review the current knowledge on GI dysmotility and enteric neuropathy associated to diabetes mellitus.

The different functional and structural alterations within the digestive tract in diabetic patients and animal models are described. Finally, the therapeutic and preventive strategies tested so far in the context of enteric diabetic neuropathy are briefly summarized. In conclusion, amongst the alterations described in DM, the loss of inhibitory intrinsic innervation of the gut is most remarkable. Key words: Diabetes mellitus.

Gastrointestinal dysmotility. Enteric neuropathy. Myenteric plexus. Enteric nervous system. DM 1 y 2: diabetes mellitus 1 y 2. GI: gastrointestinal. Presenta, entre otras, neuronas sensitivas, interneuronas y neuronas motoras excitadoras e inhibidoras de ambas capas musculares. De todas las alteraciones la mejor conocida es la gastroparesia 9. Modelos animales y estudios in vitro e in vivo. Por el contrario, en el colon la frecuencia de estas contracciones fue similar a los controles Tampoco parece que la hiperglucemia sea determinante en estos casos, ya que animales con distinto control de la glucemia mostraron cambios similares Estudios en humanos 47 parecen confirmar un comportamiento semejante al de la rata.

La susceptibilidad de los microvasos a la hiperglucemia se relaciona con la prevalencia de bacterias en diferentes partes del tracto GI ya que inducen un estado anaerobio en el intestino distal Facultad de Ciencias de la Salud.

Global estimates of diabetes prevalence for and projections for Diabetes Res Clin Pract ; American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care ;37 Supl.

Powers AC. Diabetes Mellitus. Harrison Principios de Medicina Interna. McGraw-Hill Interamericana; Furness JB. The enteric nervous system. Massachusetts: Blackwell; Neurochemical classification of myenteric neurons in the guinea-pig ileum.

Neuroscience ; Al-Shboul OA. The importance of interstitial cells of Cajal in the gastrointestinal tract. Saudi J Gastroenterol ; Drucker DJ. The role of gut hormones in glucose homeostasis. J Clin Invest ; Kopacova M. Small intestinal bacterial overgrowth syndrome. World J Gastroenterol ; Diabetic gastrointestinal autonomic neuropathy: Current status and new achievements for everyday clinical practice. Eur J Intern Med ; Diagnosis and treatment of chronic gastroparesis and chronic intestinal pseudo-obstruction.

Gastroenterol Clin N Am ; Samsom M, Smout AJ. Abnormal gastric and small intestinal motor function in diabetes mellitus. Dig Dis ; Bruna J, Navarro X. Rev Neurol ; Chandrasekharan B, Srinivasan S. Diabetes and the enteric nervous system. Neurogastroenterol Motil ; Diabetes-related alterations in the enteric nervous system and its microenvironment. World J Diabetes ; Myenteric plexus in streptozotocin-treated rats. Neurochemical and histochemical evidence for diabetic neuropathy in the gut.

Gastroenterology ; Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy. LePard KJ. Choline acetyltransferase and inducible nitric oxide synthase are increased in myenteric plexus of diabetic guinea pig.

Auton Neurosci ; Diabetic autonomic neuropathy: Evidence for apoptosis in situ in the rat. Int J Exp Pathol ; Age-dependent slowing of enteric axonal transport in insulin-resistant mice.

Gastroenterology ; Enteric neuropathy can be induced by high fat diet in vivo and palmitic acid exposure in vitro. PLoS One ;8:e Regional gastric contractility alterations in a diabetic gastroparesis mouse model: Effects of cholinergic and serotoninergic stimulation. Enhanced colonic peristalsis by impairment of nitrergic enteric neurons in spontaneously diabetic rats. Radiographic analysis of gastrointestinal motor function in a model of type 2 diabetes, the Zucker Diabetic Fatty ZDF rat.

J Diabetes ;1 Supl. Gastrointestinal motility changes and myenteric plexus alterations in spontaneously diabetic biobreeding rats.

J Neurogastroenterol Motil ; Assessment of gastric emptying in non-obese diabetic mice using a 13C -octanoic acid breath test. J Vis Exp ;e Prevention and partial reversal of diabetes-induced changes in enteric nerves of the rat ileum by combined treatment with alpha-lipoic acid and evening primrose oil. Number and ultrastructure of epithelial cells in crypts and villi along the streptozotocin-diabetic small intestine: A quantitative study on the effects of insulin and aldose reductase inhibition.

Virchows Arch ; Effects of streptozotocin-diabetes on rat intestinal mucin and goblet cells. A morphological study of the enteric mucosal epithelium in the streprozotocin-diabetic mouse. Life Sci ; Vitamin E alpha-tocopherol supplementation in diabetic rats: Effects on the proximal colon.

BMC Gastroenterol ; A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus. J Gastroenterol ; Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic gastroparesis. J Gastroenterol Hepatol ; Deficiency of KIT positive cells in the colon of patients with diabetes mellitus.

Gastroenterol Hepatol ;

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La gastroparesia

Mecanismos e fatores associados aos sintomas gastrointestinais em pacientes com diabetes melito. Foram selecionados os artigos mais atuais e representativos do tema. The most relevant and up-to-date articles on the topic were selected. The complications caused by this disease in the digestive system, such as gastrointestinal symptoms nausea, vomiting, abdominal pain, heartburn, dysphagia, constipation, diarrhea, and fecal incontinence are well known. The pathogenesis of changes in the gastrointestinal functions in patients with diabetes mellitus is still being investigated at the same time as the role of the enteric nervous system and its neurotransmitters has gained significance. As a consequence of the complications in the digestive system, which damage the enteric nervous system, patients with diabetes mellitus may have specific gastrointestinal motility disorders, some of which may be of great relevance, such as diabetic gastroparesis, constipation, and diarrhea. Gastrointestinal dysfunction increases the morbidity of diabetes mellitus and worsens the quality of life of diabetic individuals.

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Servicio de Medicina de Aparato Digestivo. Hospital Universitario 12 de Octubre. Es poco frecuente pero determina una alta morbilidad. La complejidad de estos enfermos aconseja su seguimiento multidisciplinar. Motilidad intestinal. Chronic intestinal pseudo-obstruction CIPO is a syndrome characterized by the presence of recurrent episodes of clinical intestinal obstruction in the absence of obstructive lesions. Although this syndrome is rare, it causes a high morbidity.

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