Nenhuma das mulheres estava na menopausa, sendo que todos os estudos foram realizados durante a primeira fase do ciclo menstrual. Com estes dados foram obtidas curvas de tempo versus contagem radioativa. Valores de P menores que 0,05 foram considerados como estatisticamente significativos. Scintigraphic study of gastric emptying and intragastric distribution of a solid meal: gender differences. Arq Gastroenterol ;37 2

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Universidad Rey Juan Carlos. La diabetes mellitus DM es un conjunto de enfermedades de gran prevalencia en la actualidad. Para ello se describen las diversas alteraciones funcionales y estructurales encontradas en el sistema digestivo tanto en el hombre como en diversos modelos animales de diabetes. Palabras clave: Diabetes mellitus. Dismotilidad gastrointestinal.

Diabetes mellitus DM is a group of diseases highly prevalent nowadays. Its different types produce very similar symptoms with acute and chronic complications. Amongst these, gastrointestinal GI dysmotility, associated with the development of neuropathy in the enteric nervous system ENS is recognized. The objective is to review the current knowledge on GI dysmotility and enteric neuropathy associated to diabetes mellitus.

The different functional and structural alterations within the digestive tract in diabetic patients and animal models are described. Finally, the therapeutic and preventive strategies tested so far in the context of enteric diabetic neuropathy are briefly summarized. In conclusion, amongst the alterations described in DM, the loss of inhibitory intrinsic innervation of the gut is most remarkable. Key words: Diabetes mellitus.

Gastrointestinal dysmotility. Enteric neuropathy. Myenteric plexus. Enteric nervous system. DM 1 y 2: diabetes mellitus 1 y 2. GI: gastrointestinal. Presenta, entre otras, neuronas sensitivas, interneuronas y neuronas motoras excitadoras e inhibidoras de ambas capas musculares. De todas las alteraciones la mejor conocida es la gastroparesia 9. Modelos animales y estudios in vitro e in vivo. Por el contrario, en el colon la frecuencia de estas contracciones fue similar a los controles Tampoco parece que la hiperglucemia sea determinante en estos casos, ya que animales con distinto control de la glucemia mostraron cambios similares Estudios en humanos 47 parecen confirmar un comportamiento semejante al de la rata.

La susceptibilidad de los microvasos a la hiperglucemia se relaciona con la prevalencia de bacterias en diferentes partes del tracto GI ya que inducen un estado anaerobio en el intestino distal Facultad de Ciencias de la Salud.

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Gastroenterol Hepatol ;


La gastroparesia

Mecanismos e fatores associados aos sintomas gastrointestinais em pacientes com diabetes melito. Foram selecionados os artigos mais atuais e representativos do tema. The most relevant and up-to-date articles on the topic were selected. The complications caused by this disease in the digestive system, such as gastrointestinal symptoms nausea, vomiting, abdominal pain, heartburn, dysphagia, constipation, diarrhea, and fecal incontinence are well known. The pathogenesis of changes in the gastrointestinal functions in patients with diabetes mellitus is still being investigated at the same time as the role of the enteric nervous system and its neurotransmitters has gained significance. As a consequence of the complications in the digestive system, which damage the enteric nervous system, patients with diabetes mellitus may have specific gastrointestinal motility disorders, some of which may be of great relevance, such as diabetic gastroparesis, constipation, and diarrhea. Gastrointestinal dysfunction increases the morbidity of diabetes mellitus and worsens the quality of life of diabetic individuals.


Servicio de Medicina de Aparato Digestivo. Hospital Universitario 12 de Octubre. Es poco frecuente pero determina una alta morbilidad. La complejidad de estos enfermos aconseja su seguimiento multidisciplinar. Motilidad intestinal. Chronic intestinal pseudo-obstruction CIPO is a syndrome characterized by the presence of recurrent episodes of clinical intestinal obstruction in the absence of obstructive lesions. Although this syndrome is rare, it causes a high morbidity.



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