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Free to read. The few geneticists who are interested in leprosy have been working in this field only since , and have made little progress in solving the problems presented by susceptibility to this disease. This paper reviews the research that has been conducted, with particular reference to the search for associations between leprosy and certain genetic markers. In each area, the advantages and limitations of different techniques are described, and attention is drawn to sources of bias that may invalidate many of the results that have been published.
Of particular interest is the discussion of a new technique for evaluating resistance to-leprosy. The proposed technique is based upon the in vitro transformation of blood monocytes into macrophages, and the observation of their behaviour against Mycobacterium leprae. Pathol Biol Paris , 61 3 , 24 May Cited by 4 articles PMID: Future Microbiol , 6 5 , 01 May Cited by 42 articles PMID: Infect Immun , 59 9 , 01 Sep Clin Microbiol Rev , 1 3 , 01 Jul Review Free to read.
Clin Exp Immunol , 44 3 , 01 Jun Cited by 1 article PMID: To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. Lagrange PH , Abel L. Acta Leprol , 10 1 , 01 Jan Cited by 5 articles PMID: Fine PE.
Author information Copyright and License information Disclaimer. Copyright notice. This article has been cited by other articles in PMC. Abstract The few geneticists who are interested in leprosy have been working in this field only since , and have made little progress in solving the problems presented by susceptibility to this disease. A relationship between cancer of stomach and the ABO blood groups.
Br Med J. The blood groups in relation to peptic ulceration and carcinoma of colon, rectum, breast, and bronchus; an association between the ABO groups and peptic ulceration.
The binding of haemoglobin by plasma proteins haptoglobins ; its bearing on the renal threshold for haemoglobin and the aetiology of haemoglobinuria. Blood groups of gastric ulcer and carcinoma. Rev Bras Leprol. The genetics of resistance to leprosy. Int J Lepr. Fecundidade e lepra. Rev Paul Med. Nature and familial character of the lepromin reactions. Influence of repeated lepromin injections on the Mitsuda skin reaction. The hemolytic effect of primaquine and related compounds: a review.
Bull N Y Acad Med. Conjectures on inherited susceptibility to lepromatous leprosy. Ethnologic aspects of the ABO blood groups disease associations. J Am Med Assoc. ABO blood groups and disease. The association of the ABO blood groups to gastric carcinoma.
Surg Gynecol Obstet. Distribution of ABO blood groups and the secretor status in duodenal ulcer families. Secretion of blood group antigens and peptic ulcer. ABO blood groups and secretor character in duodenal ulcer; population and sibship studies.
Hemolytic anemia induced by sulfoxone therapy, with investigations into the mechanisms of its production. Am J Med. The Relationship between Chemical Constitution and Taste. Cretinism and taste sensitivity to phenylthiocarbamide. The existence of the glucosephosphate dehydrogenase deficiency trait in Nigeria and its clinical implications. Ann Trop Med Parasitol.
Glucosephosphate dehydrogenase deficiency trait in Nigeria. Some cytochemical and cytophysiological properties of the cells from tuberculoid and lepromatous lesions.
Lepr Rev. An attempt to stimulate and depress the functional activity of the inflammatory cells from lesions experimentally induced by M. Estudo da sensibilidade tuberculinica em cobaios normais inoculados experimentalmente com M. The measurement of taste sensitivity to phenylthiourea.
Ann Eugen. Taste sensitivity to phenylthiourea in goitre and diabetes. ABO blood-groups and gastric acidity. Serum haptoglobins in hepatobiliary disease. Increased incidence of non-tasters of phenylthiocarbamide among congenital athyreotic cretins. Genetics and the epidemiology of leprosy. The incidence of leprosy. The form of leprosy. Observations on the results of pregnancies in women resident in Belfast. Abortions, hydatidiform moles and ectopic pregnancies. Ann Hum Genet. Enzymatic abnormality in erythrocytes of a population sensitive to Vicia faba or haemolytic anemia induced by drugs.
Leprosy and A. Associated Data Supplementary Materials. Open in a separate window. Leprosy susceptibility: genetic variations regulate innate and adaptive immunity, and disease outcome.
Effects of activated macrophages on Mycobacterium leprae. Failure to induce delayed-type hypersensitivity to Mycobacterium leprae in long-term treated lepromatous leprosy patients. Immunogenetics of susceptibility to leprosy, tuberculosis, and leishmaniasis. An epidemiological perspective. Genetic dissection of immunity in leprosy.
Factors influencing the level of dapsone in blood
Beiguelman, Bernardo Overview. Publication Timeline. Most widely held works by Bernardo Beiguelman. Genetica Medica by Bernardo Beiguelman Book 3 editions published in in Portuguese and held by 6 WorldCat member libraries worldwide. Farmacogenetica e sistemas sanguineos eritrocitarios by Bernardo Beiguelman Book 2 editions published in in Portuguese and held by 4 WorldCat member libraries worldwide. Organizador: P.
Leprosy and genetics. A review of past research with remarks concerning future investigations.
The level of dapsone in the blood 4 and 6 h after the ingestion of the 7th daily dose of mg of the drug was investigated in 36 adult males with leprosy who had normal renal function and were free of diarrhoea and emesis. The bimodal distribution of the dapsone levels at 6 h was shown by multiple regression analysis to be due to a negative correlation between this trait and the haematocrit value. Among the patients with high dapsone blood levels, Partial regression coefficients, calculated for the dapsone level on the age, weight of the patient, estimated number of years since the onset of leprosy, number of years under sulfone treatment, and blood levels of haemoglobin, albumin, and globulins, did not show statistical significance. National Center for Biotechnology Information , U.
Bernardo Beiguelman It was there where he went to school and initiated his first studies. After graduating he became a high school teacher, and at the same time, moved by his restless personality, started, almost as an autodidact a study on the Cerrado flora and soon introduced into his teaching activities examples taken from scientific work on the physiology of peculiar plants of this biome. This research on the physiology of certain plant species composing the Cerrado vegetation was the building block for his doctoral thesis and marked the start of a brilliant scientific career. During his scientific career he was the author of more than scientific contributions, including books, book chapters, original scientific articles and scientific communications at Congresses held both in Brazil and several foreign countries.